Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis (EAE)
نویسندگان
چکیده
Thank you for the submission of your manuscript "Inhibition of the immunoproteasome strongly ameliorates experimental autoimmune encephalomyelitis (EAE)". We have now heard back from the three referees whom we asked to evaluate your manuscript. As you will see, the referees acknowledge that the overall topic of the manuscript is potentially interesting. However, they also raise significant concerns, which, I am afraid, preclude publication of the manuscript in EMBO Molecular Medicine.
منابع مشابه
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function of immunoproteasomes in cytokine production and T cell differentiation. In this study, we investigated the therapeutic efficacy of an inhibito...
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Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of NMDARs has been suggested for neuroprotection, but selective antagonisation of the NR2B subtype of these receptors, a subtype believed to play a more pivotal ...
متن کاملInhibition of NR2B-Containing N-methyl-D-Aspartate Receptors (NMDARs) in Experimental Autoimmune Encephalomyelitis, a Model of Multiple Sclerosis
Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of NMDARs has been suggested for neuroprotection, but selective antagonisation of the NR2B subtype of these receptors, a subtype believed to play a more pivotal ...
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Background: Leukocyte infiltration into the central nervous system (CNS) in diseases like multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. It suggested that vitamin D3 (active form of vitamin D) ameliorates the symptoms of EAE when administered after the onset of clinical sings. The aim of this s...
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